Real Plenity Reviews: Weight Loss Results, Cost, Side Effects, Buy Guide

If you’re looking for real reviews on Plenity weight loss pill you have come to the right place. This dietary supplement has been shown to help users lose weight over time. In this Plenity review, we will discuss how much weight can be lost with the diet pill, as well as whether or not it is safe to use. We will also provide information on where to buy Plenity.

Plenity real reviews
Real Plenity Review: How Much Weight Can I Lose and Is It Safe to Use?

Plenity Review Summary: As far as we can see, Plenity and glucomannan could be used interchangeably. There is unlikely to be much difference between them other than the price. Using Plenity for a month would cost you three times as much money as using a basic glucomannan weight loss pill.

Pros: FDA approved diet pill, fewer side effects than other similar weight loss pills, has some weight loss results from past users.

Cons: Prescription only, not available in lots of pharmacies, has some side effects, expensive

Some of the premium natural weight loss supplements have similar weight loss results to Plenity but without side effects. Comparable natural diet supplements are also less expensive and easier to obtain over the counter or online. Read our weight loss pills over the counter guide.

Plenity Review Introduction

If you are overweight (BMI 25+) or obese (BMI 30+), Plenity is a weight loss product that may be available to you. However, as with most alternative weight loss products, Plenity has its pros and cons.

One of the most attractive things about Plenity is it’s approved by the American Food and Drug Administration (FDA). Very few weight management treatments gain FDA approved so it’s one of the options on a very short list.

All the other FDA-approved weight loss treatments, such as Phentermine (prescription appetite suppressant) are chemical based. They also have many known side effects and some of them can be habit-forming.

Plenity is a natural product that’s stimulant-free, non-addictive, and has fewer side effects than other FDA-approved options. These things work in its favor too.

However, as with other FDA-Approved treatments, you will require a prescription to use Plenity. For some people, this will make Plenity less enticing than over-the-counter (OTC) weight loss supplements. 

One of the other less attractive things about Plenity is your family doctor will not be able to provide you with a prescription. Nor will you be able to buy it via a local pharmacy.

If you want to lose weight with Plenity, you have to visit the manufacturer’s website and obtain a prescription by filling in an online health questionnaire, If you are successful in qualifying for a prescription, you will have to buy the treatment via the site.

The price is an issue with Plenity too. Using it can be more costly than most other prescription-only weight loss treatments, all of which cost a lot more than any of the best OTC weight loss pills.

What Is Plenity?

Plenity is a prescription weight loss treatment you take orally. Like many other diet pills, it’s produced in capsule form. The capsule consists of two push-together casings that trap the active ingredients inside.

Plenity was created by researchers at Gelesis and is presently manufactured and distributed by the Roman telehealth company. At the time of this review, a 4-week supply of Plenity cost $98. We feel that’s expensive.

As with all the other weight management treatments approved by the FDA, Plenity is only available to people who have a BMI of 25 or higher. It’s intended to be used alongside a structured weight management regimen that includes a suitable diet plan and regular exercise.

Due to the risk of side effects and/or addiction, most of the FDA-approved weight management options are only available as short-term treatments. Typically for no more than a maximum of three months.

Because Plenity does not present the same level of risk as most of the other approved weight loss treatments, there are no restrictions on how long you can use it. Needless to say, though, your prescription will cease when your BMI drops to less than 25.

Who is Plenity For?

Plenity is intended for overweight and obese adults who have tried other methods of weight loss without success. Plenity diet pill is not intended for children, pregnant women, or people with eating disorders. If you are considering taking Plenity, talk to your doctor first to see if it is right for you.

How Does Plenity Work?

Plenity is an appetite suppressant. Weight loss pills of this type make it easier for you to lose weight by controlling hunger. Like many other appetite suppressants, Plenity achieves this by making your stomach feel full.

When your stomach feels full, it limits the amount of food you can eat. More importantly, it reduces the desire to eat. Appetite suppressants, such as Plenity, can be a valuable aid to anyone following a low-calorie diet.

However, although hunger control is important, it’s only one aspect that can affect your weight loss results. Most of the best OTC diet pills control hunger  and provide support in other areas as well.

The main thing appetite suppressants do is make losing weight less unpleasant. Nobody enjoys feeling hungry. It’s a horrible sensation that’s very distracting and can make it hard to concentrate on the things you need to do throughout the day.

It’s much easier to give in to hunger than it is to fight it. That’s what many people do. It’s the main reason so many diets fail.

Plenity reviews from real customers suggest Plenity works well as an appetite suppressant. We are not knocking its ability. By making it easier to eat less and stick to smaller portion sizes at mealtimes, the treatment should help you to maintain the energy shortage (lack of calories) that forces your body to burn its fat.

Unfortunately, this is all Plenity does. The best OTC alternatives to Plenity control hunger as well. However, they also increase metabolism to help you to burn more calories per day than you could with diet and exercise alone.

They may help in other areas as well, such as enhancing mood and preventing fatigue. They don’t just make weight loss easier, they make it faster too.

Plenity Weight Loss Benefits

  • Clinically tested and FDA-approved
  • Stimulant-free
  • Non-addictive
  • Free 2-day shipping
  • Free unlimited telehealth follow-ups

How to Use Plenity

To make the most progress and ensure your success, you need to use Plenity alongside diet and exercise. Only two doses are required each day. You take the first one 20 minutes before lunch and the second one 20 minutes before dinner.

Each dose consists of three Plenity capsules, taken with water.

Adequate fluid is necessary to activate Plenity’s weight loss ingredient so it’s important to be sure to take each dose with at least 16 oz of water. If you don’t Plenity will offer little or no appetite support.

What are the Ingredients in Plenity?

The Roman telehealth website does not provide a full ingredient profile but the key ingredient is cellulose. The formulation also has some citric acid.

Cellulose is an indigestible compound that’s present in many vegetables including cumber and lettuce. It’s the main structural component of plant cell walls. 


The combination of cellulose and citric acid forms a unique 3D hydrogel matrix that can hold up to 100 times its weight in water. 

However, it’s unclear if the cellulose in Plenity is a standard plant extract. According to Roman, Plenity utilizes a system of “biomimicry” that allows it to mimic the structure of cellulose.

Method of Action – How Does Plenity Work

After the capsule coating dissolves and releases its contents, the cellulose retains its structure and combines with water. The hydration process creates a gel that consists of individual cells. Each one can hold 100 times its weight in water.

These cells mix with the food from the meal that follows, bulking it up and adding extra volume. This increases satiety, making the stomach feel full after smaller quantities of food.

The appetite suppressing effect can last quite a long time but does not affect your ability to digest food or obtain its energy and nutrients.

When the compound reaches the large intestine, the digestive enzymes cause the hydrogel to lose its 3-dimensional structure and release the water locked inside. The intestines process the water in the normal way but the cellulose, which remains indigestible, is eventually expelled from the body with the feces.

What the Research Shows

Most of the claims about Plenity and weight loss are based on the findings of a single study.

Although the study results look good, it’s important to be aware the funding for the study was provided by Gelesis. When studies are funded by companies that will profit from the success of the products being evaluated, it’s hard to consider the results unbiased.

The “GLOW” (Gelesis Loss of Weight) clinical trial ran for 24 weeks. Four hundred and thirty-six people took part.

As is generally the case with studies of this nature, not all the participants were given Plenity. Some of them served as a control group and got a placebo.

Regardless of whether they were receiving Plenity of the placebo, both groups made similar efforts with diet and exercise.

By the end of the study, the people assigned to the Plenty group had lost more weight than the ones in the placebo group. However, the difference could hardly be called dramatic. They only lost 2.1% more weight than the study participants taking the placebo.

The predefined “super-superiority” margin was 3% and the gel-compound now being marketed as Plenity failed to meet it. If you consider this carefully, you will realize the actual success rate was around 33% lower than Gelesis anticipated.

So, although the study was a success in one way, it was a miserable failure in another.


Notable Points About the Participant Selection Criteria

It’s worth noting the choice of study participants was unusual. The researchers only accepted individuals with fasting blood glucose levels between 90 and 145 mg/dl. 

Glucose levels in pre-diabetes are 100-125 mg/dl. The Center for Disease Control (CDC), states anyone with a blood glucose level over 125 mg/dl is a full-blown diabetic.

Why is this is important? Because the selection criteria suggest most of the study participants may have been either diabetic or pre-diabetic. Most people seeking weight loss support are not. It’s hard not to question if the study data would have been the same if Gelesis had selected study participants with blood sugar levels more akin to the average individual requiring weight loss support.

Plenity Side Effects

The GLOW study results say there were no significant differences in side effects between the Plenity group and the placebo group.

However, the FAQ page on the Roman telecare website provides a list of potential side effects. 

Most of the side effects are stomach or gut-related. Nothing scary. Just the minor problems you might experience if you were to suddenly up your intake of dietary fiber.

Interestingly, the FAQ page also reveals the side effects percentages from both groups.

Although the researchers did not consider the difference significant, the participants taking Plenity had more side effects than the members of the placebo group ‒ right across the board.

Plentity GroupPlacebo Group
Abdominal distension12%7%
Infrequent bowel movements9%5%

Plenity Pros and Cons


  • FDA-approved weight management treatment
  • Appears to work better than a placebo
  • Easy to use
  • Fewer side effects than other prescription weight loss options
  • Suitable for long-term use


  • Only available via prescription
  • Only available to people who have a high BMI
  • Not available through traditional pharmacies
  • Manufacturer funded study
  • May cause side effects
  • Failed to achieve weight loss super-superiority margin of 3% over placebo
  • More expensive than OTC weight loss alternatives

Plenity Review Conclusion

At the beginning of this Plenity review, we pointed out that Plenity has many pros and cons. Then, throughout the review, we listed the good and bad points of Plenity, as and when appropriate.

We also provided a pros and cons comparison so you can see the good and bad points side by side.

Because severe side effects are so unlikely, many people may find Plenity a more attractive option than most of the other prescription anti-obesity treatments such as Phentermine and Orlistat.

The fact that it’s suitable for long-term use is also a plus.

Although we have some doubts about the credibility of the GLOW study, we are confident in Plenity’s ability to suppress appetite. Glucomannan works in the same way.

Glucomannan is a root extract that’s present in many of the top appetite suppressing supplements. Like Plenity, it soaks up water and expands in the stomach to increase satiety. Its ability to control hunger has been evaluated and confirmed by the European Food Safety Authority (EFSA).

As far as we can see, Plenity and glucomannan could be used interchangeably. There is unlikely to be much difference between them other than the price. Using Plenity for a month would cost you three times as much money as using a basic glucomannan weight loss pill.

Glucomannan is also a key ingredient in some of the top-rated diet pills, In addition to controlling hunger, these OTC weight loss supplements also speed up fat loss and provide additional support as well.

The other problem with Plenity, is you only take it two times a day. Some of the best OTC alternatives are taken three times per day (breakfast, lunch dinner) and most of them have money-back guarantees. In our option, they offer much better value for money.

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about the author

Madeline is a professional dietician and journalist with many years of experience. She writes on human health and reviews products with expertise, knowledge and wit. Madeline is fluent in English, French and Italian.